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Depot injection:
Body weight: Less than or equal to 25 kg: mg IM once a month
Body weight: Greater than 25 kg to kg: mg IM once a month
Body weight: Greater than kg: 15 mg IM once a month

Comments:
-Hormonal levels should be tested after 1 to 2 months of therapy and with each dose change to ensure adequate pituitary gonadotropin suppression.
-Once a dose that results in adequate hormonal suppression, it can often be maintained for the duration of therapy in most children; however, hormonal suppression should be verified as weight can increase significantly while on therapy.

Subcutaneous Injection:
Initial dose: 50 mcg/kg/day subcutaneously. If total downregulation is not achieved, the dose should be titrated upward by 10 mcg/kg/day. This dose will be considered the maintenance dose.

Comments:
-The dosage should be adjusted for weight changes.
-Discontinuation of therapy be considered before age 11 for females and before age 12 for males.

Use: Treatment of children with central precocious puberty (CPP)

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