Sex hormone-binding globulin (SHBG) is thought to mainly function as a transporter and reservoir for the estradiol and testosterone sex hormones. However it has also been demonstrated that SHBG can bind to a cell surface receptor (SHBG-R). The SHBG-R has not been completely characterized. A subset of steroids are able to bind to the SHBG/SHBG-R complex resulting in an activation of adenylyl cyclase and synthesis of the cAMP second messenger.  Hence the SHBG/SHBG-R complex appears to act as a transmembrane steroid receptor that is capable of transmitting signals to the interior of cells.
Anaphylaxis (anaphylactic shock) occurs when the body’s immune system overreacts to a substance, such as a food item. It is an unpredictable condition that can be life threatening. EpiPen is an adrenaline auto-injector used for the acute treatment of anaphylactic shock or severe allergic reactions to allergens, . insect bites or foods. Meda has received a label extension for EpiPen and the product is now also intended for immediate administration in patients who are determined to be at increased risk of anaphylaxis (including patients with a history of anaphylactic reactions). People at risk of anaphylactic shock should always carry an adrenaline injector. The at-risk indication is further endorsed by the new guidelines of the European Academy of Allergy and Clinical Immunology (EAACI).