Jaime V… THANK YOU THANK YOU THANK YOU!!!!!!! This has to be the most helpful post on the Internet and I haven’t even begun taking my metformin yet. I have celiac, Fatty Liver Disease, IBS, and was just diagnosed with PCOS. By the grace of God I was able to have 3 children. I was very young with the first one, took eight years and BC (regulate my periods) to get pregnant with second child and four years after that the only way I was able to get pregnant with my 3rd child was with the use of Provera. Don’t know why it took so long, but finally figured out why I have become “The Great Bearded Woman” lol.
While Leone developed Vincenzoni's idea into a script, the screenwriter recommended the comedy-writing team of Agenore Incrucci and Furio Scarpelli to work on it with Leone and Sergio Donati. According to Leone, "I couldn't use a single thing they'd written. It was the grossest deception of my life."  Donati agreed, saying, "There was next to nothing of them in the final script. They only wrote the first part. Just one line."  Vincenzoni claims that he wrote the screenplay in 11 days, but he soon left the project after his relationship with Leone soured. The three main characters all contain autobiographical elements of Leone. In an interview he said, "[ Sentenza ] has no spirit, he's a professional in the most banal sense of the term. Like a robot. This isn't the case with the other two. On the methodical and careful side of my character, I'd be nearer il Biondo ( Blondie ): but my most profound sympathy always goes towards the Tuco side ... He can be touching with all that tenderness and all that wounded humanity."  Film director Alex Cox suggests that the cemetery-buried gold hunted by the protagonists may have been inspired by rumours surrounding the anti-Communist Gladio terrorists, who hid many of their 138 weapons caches in cemeteries. 
It is possible that some people, for reasons unknown, just can't tolerate Noni juice. Advocates of Morinda citrifolia place these folks in the minority and continue to focus on the health benefits of the drink. Critics warn that these side effects are too common and too severe for consumers to continue buying and consuming Noni juice.
Noni juice is lauded by some as a miracle drink, and shunned by others as hazardous poison. Anecdotal evidence is all we have at this point to determine the value of Noni juice as a medicinal supplement. As with all herbal medicines, the consumer is pretty much "on his own" until medical science has more information to share about the usefulness and safety of this controversial product.