Addiction to cortisone was the subject of the 1956 motion picture, Bigger Than Life , produced by and starring James Mason . Though it was a box-office flop upon its initial release,  many modern critics hail it as a masterpiece and brilliant indictment of contemporary attitudes towards mental illness and addiction.  In 1963, Jean-Luc Godard named it one of the ten best American sound films ever made.  John F. Kennedy needed to regularly use corticosteroids such as cortisone as a treatment for Addison's disease . 
Glucocorticoids, particularly cortisol , promote the conversion of fats to carbohydrates and the deposition of glycogen (a storage form of glucose) in the liver and participate in maintaining normal blood-sugar concentrations. The production of glucocorticoids is regulated by adrenocorticotropic hormone , secreted by the pituitary gland . They also play a minor part in regulating the excretion of mineral salts and water, but the most powerful of the hormones exerting this mineralocorticoid effect is aldosterone: it controls sodium metabolism in mammals and promotes the excretion of magnesium in the urine.