Under maximal acid stimulatory conditions using pentagastrin, a dose-dependent decrease in gastric acid output occurs after a single dose of oral (20 mg to 80 mg) or a single dose of intravenous (20 mg to 120 mg) Pantoprazole in healthy subjects. Pantoprazole given once daily results in increasing inhibition of gastric acid secretion. Following the initial oral dose of 40 mg Pantoprazole, a 51% mean inhibition was achieved by hours. With once-a-day dosing for 7 days, the mean inhibition was increased to 85%. Pantoprazole suppressed acid secretion in excess of 95% in half of the subjects. Acid secretion had returned to normal within a week after the last dose of Pantoprazole; there was no evidence of rebound hypersecretion.
Scientists have started to distinguish functional RNA ( fRNA ) from ncRNA, to describe regions functional at the RNA level that may or may not be stand-alone RNA transcripts.    This implies that fRNA (such as riboswitches, SECIS elements, and other cis-regulatory regions) is not ncRNA. Yet fRNA could also include mRNA , as this is RNA coding for protein, and hence is functional. Additionally artificially evolved RNAs also fall under the fRNA umbrella term. Some publications  state that ncRNA and fRNA are nearly synonymous, however others have pointed out that a large proportion of annotated ncRNAs likely have no function.   It also has been suggested to simply use the term RNA , since the distinction from a protein coding RNA ( messenger RNA ) is already given by the qualifier mRNA .  This eliminates the ambiguity when addressing a gene "encoding a non-coding" RNA.