Alternative creams that can be used on the face include the Elidel and Protopic , which are topical calcineurin inhibitors (TCIs). These medications are approved by the FDA for the treatment of atopic dermatitis in people 2 years of age and older. Unlike topical steroids, TCIs do not cause skin thinning, pigment changes, blood vessel formation, or striae formation, nor do they lose effectiveness with prolonged use. In addition, TCIs can be used on any skin, including the face and eyelids. Just like any medication, however, even TCIs have possible side effects. Learn about the FDA warnings associated with Elidel and Protopic .