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To calculate the numerator: The cause/mechanism of each adverse drug event visit is coded as allergic reaction, side-effect or overdose. Only ED visits due to overdoses are included in the numerator. In addition, up to two drugs may be implicated in the adverse event. If an injectable antidiabetic agent appears as an implicated drug, the associated ED visit is included in the numerator. To calculate the denominator: Up to eight drugs may be identified as prescribed or continued during the outpatient visit. If an injectable antidiabetic agent appears as a prescribed or continued drug, the associated outpatient visit is included in the denominator.